My setup is as simple as it can be – I simply run the XLR out straight to the board or recording interface. You can really use it however you’d like – run it into an amp, run it into a FRFR speaker, use it with an amp with the 4 cable method, but in my experience, the simplicity of the XLR out is the way to go.
When setting up patches, there are a few things to consider. I always like to make sure I’m setting up tones in the same setup as I use it live. If you run that XLR out to a board, you’re running it into a preamp and then through an EQ strip then out through main speakers (the standard channel strip on a sound board). So I like to recreate that signal flow. I hook it up via the XLR into an audio interface – for me that’s a Universal Audio Apollo. That re-creates the XLR out into a preamp. Then I monitor through a set of studio monitors – Tannoy 5 in. powered monitors. I find this to be a very accurate way to set up patches – what I hear out of my monitors is the same as what I hear out of the main speakers where I lead worship.
I know many people use the headphone out to set up patches, and I think this is why many people express that the headphone tone doesn’t match what comes out of the speakers in their venues. There are certainly a lot of factors in play (the sound board being used, the main speakers, the room itself, and the person behind that sound board for starters), but the headphone out can sound a bit different than the XLR out to a board.